According to a 2014 study published in the Journal of Psychopharmacology, participants with Parkinsons Disease taking 75 or 300 milligrams (mg) of cannabidiol (CBD) per day reported moderate (75mg group) to significant (300mg group) improvement in their quality of life.
While these doses might seem high to some of our customers, its important to note that study participants took CBD isolate filled gelcaps, which only have a bioavailability of about 6%* compared to significantly higher (+15%) numbers for tinctures held under the tongue or via vaporization.
*Its important to note that while 300 mg-CBD/day had a greater effect than 75 mg/day, the participants consumed CBD isolate filled gel capsules. Ignoring for a moment the widely held belief that the CBD in full spectrum oils is more potent, the bioavailability of merely consumed (i.e. swallowed, not held under the tongue or vaporized) is only 6%, thus for the 300-mg group, their bodies likely only absorbed 18mg of CBD. Bioavailability for vaporization can be as high as 65% (source: https://www.ncbi.nlm.nih.gov/pubmed/23685330) and sublingual tincture bioavailability can be anywhere from 15-40% according to several studies we’ve seen. Assuming a sublingual bioavailability of 18%, 100 mg-CBD/day held under the tongue for 30-60 seconds would have had the same effect as the 300mg pills.
Disclaimer: These statements (especially the bottom paragraph) have not been evaluated by the FDA.